Antigon is a new medication that will allow IVF doctors to utilize IVF stimulation protocols without requiring the use of Lupron. Like Lupron, Antigon blocks the Luteinizing Hormone surge that, if occurring prematurely, will jeopardize a successful egg retrieval by causing premature release of the eggs from the follicles. Consequently Gonadotropin stimulation can be successfully employed for IVF without the fear of losing eggs prior to the retrieval. When the follicles reach 14 mm Antigon is given along with the usual Gonadotropin dosage. This usually requires three to four injections until the eggs are mature enough for HCG injection.

Antigon is also useful in cases in which natural cycle IVF is employed. Although natural cycle IVF is not as successful in achieving pregnancy as IVF with ovarian stimulation, in certain cases, it may be an appropriate choice of protocol. Using Antigon, the single egg follicle can be allowed to mature without risking egg release prior to retrieval. In patients who are too profoundly suppressed by Lupron, Antigon will allow ovarian stimulation using Gonadotropins or Clomid alone. The role of Antigon in IVF protocols will soon be established because it will allow physicians to customize IVF stimulation protocols to suit individuals who do not respond well to the established medication regimens.