The Advanced Fertility Blog

IVF Success Rates vs. IUI Success Rates

Today, most couples opt to move on to IVF after failing 2 to 3 IUI cycles to increase their chances of getting pregnant. IVF success rates are improving with today’s state-of-the-art specialized knowledge and technological advantages, according to fertility specialist Dr. Hugh D. Melnick – Founder and Medical Director of Advanced Fertility Services. As a pioneering IVF specialist, the Doctor has successfully helped 1000s of patient overcome their infertility for over 40 years.


IVF Success Rates

Excessive IUI cycles add up in cost – fast. Not just financial cost – emotional, mental, and physical cost. Most patients want to graduate to IVF because of the procedure’s high success rates over protracted and failed IUI cycles. IVF is the most cost-effective infertility treatment therapy.

Dr. Melnick has compiled some facts to lessen your confusion about the basic differences between IVF and IUI success rates.

IVF Recommendation

IVF is recommended for women who have failed to achieve a pregnancy after undergoing a 2 or 3 cycles of IUI.

  • Advanced maternal age of a woman – typically, over 35 years of age
  • Blocked or damaged fallopian tubes
  • Endometriosis
  • Ovulation disorders – premature ovarian failure or uterine fibroids
  • Lack of fallopian tubes due to surgical removal
  • Genetic disorder
  • Male factor infertility, including blockage, decreased sperm count or motility
  • Unexplained infertility

IUI Recommendation


IUI is commonly prescribed as a first option for women who have been unable to conceive after one year of unprotected sexual intercourse.

  • Women who have unobstructed fallopian tubes
  • Women who have a normal uterine cavity
  • Women whose male partner has unexplained infertility

Procedure Setting

  • IVF is a simple outpatient surgical procedure performed under local anesthesia – the patient can resume normal activities the day after the procedure
  • IUI is performed in the doctor’s office and requires no anesthesia – it is similar to a Pap smear

Ovarian Follicle Growth

  • IVF – The patient is administered a series of hormone medication injections to stimulate the development of multiple follicles through the stage of egg maturity.
  • IUI – The patient is administered an oral medication (typically, Clomid or Femara) – sometimes in combination with an injectable fertility drug – during her cycle to stimulate egg production.

Union of Eggs with Sperm


  • The development of the patient’s egg follicles are monitored throughout the woman’s egg growth stage of her cycle with blood level hormone measurements and pelvic ultrasounds.
  • The doctor determines the prime time to induce ovulation via hCG injection administration.
  • The patient’s eggs are surgically retrieved by the doctor using a transvaginal ultrasound-guided aspiration tool.
  • The patient’s eggs are then fertilized with sperm in a controlled embryological laboratory.
  • All resulting embryos are continuously monitored until they reach an optimum stage of development.
  • One or more high grade embryo(s) are then transferred to the woman’s uterus via an insemination catheter.
  • IVF is a costly procedure, however, the patient has the option of electing to freeze excess embryos for future transfers should the first attempt fail.


  • The development of the patient’s egg follicles are monitored throughout the woman’s egg growth stage of her cycle with blood level hormone measurements and pelvic ultrasounds.
  • The doctor determines the prime time to induce ovulation via hCG injection administration.
  • The patient’s male partner’s sperm specimen is produced in the doctor’s office (or frozen donor sperm is retrieved) and prepared in a laboratory setting using special viability enhancement solutions.
  • The semen specimen is washed and prepared for insertion into the woman’s uterus using an insemination catheter.
  • The preparation and insertion of the sperm assures that a highly concentrated amount of mobile and active sperm are placed directly into the woman’s uterus.
  • Usually 2 IUI inseminations are performed after the hCG ovulation release injection – between 12 and 36 hours after administration – to increase the chance of conception.
  • IUI provides a low cost infertility treatment alternative for increasing a woman’s chance of pregnancy.

IVF Medications

Medications administered in conjunction with IVF are proven to be successful. A wide selection of fertility drug injections are available in the United States market today.

IVF medications are used as in the treatment of women with ovulation disorders causing their inability to produce eggs and ovulate. IVF medications are used to adjust a woman’s hormone levels and increase the chance of a successful pregnancy.

Hormonal adjustments through IVF medications are used to:

  • Stimulate the production of multiple egg follicles,
  • Trigger the release of eggs,
  • Suppress the release of eggs, or
  • Otherwise regulate ovulation

IVF Superovulation Medications

Superovulation with Gonadotropins are used to treat infertility by stimulating a woman’s ovaries to develop multiple egg follicles.

  • Follicle Stimulating Hormones (FSH). This medication stimulates the development and growth of eggs in a woman’s ovaries. Common brand names that are most successful: Follistim, and Gonal-F.
  • Gonadotropin Releasing Hormone Antagonist (GnRH antagonist). These medications are used to regulate female hormone responses and may be used in conjunction with FSH medications. Common brand names: Ganirelix and Cetrotide.
  • Letrozole (trade name: Femara) is an IVF medication that has most recently been incorporated into the regiment of drugs used for fertility treatment. This medication can be used to stimulate the growth and release of an egg follicle in women who are unable to ovulate naturally – ovulation induction. Femara also increases the chances of pregnancy in women who are able to ovulate and produce what is known as “superovulation.” Letrozole is part of the class of IVF medications called aromatase inhibitors – aromatase is an enzyme that produces estrogen.
  • Lupron is a gonadotropin-releasing hormone agonist that inhibits the woman’s pituitary gland’s ability to control the ovary and prevents the ovary from prematurely releasing egg follicles during the IVF cycle.

Human Chorionic Gonadotropin (hCG) – commonly known as a ovulation trigger injection – is an IVF medication typically used when the doctor has determined through blood tests and sonograms that your egg follicles have matured and are ready to be released from the ovaries. Common brand names: Novarel, Ovidrel, Pregnyl, and Profasi.

Progesterone is produced by the ovaries after a woman ovulates. In the IVF cycle progesterone is produced after the hCG trigger injection. Progesterone is supplemented after the hCG trigger injection via vaginal suppository or intra-muscular injections – or both. Progesterone prepares the development of the woman’s uterine lining for the implantation of the embryo(s).

Affordable IVF Specialist

Dr. Hugh Melnick founded the first private freestanding IVF center in New York in 1983. The Doctors has introduced revolutionary, cost-effective IVF treatment programs. Place your financial stress on hold by taking advantage of Dr. Hugh D. Melnick’s customized 3 Cycle IVF Solution.

  • The cost of multiple IVFs is amortized over 3 Fresh IVF Treatment Cycles
  • Should you get pregnant in Cycle 1 – then, Cycles 2 and 3 are not necessary
  • If you get pregnant in Cycle 2, of course, Cycle 3 is then not necessary

Advanced Fertility Services breaks down your cost of multiple IVF attempts and spreads out the financial risk over 3 fresh IVF cycles.

  • Cycle 1 = $9,500
  • Cycle 2 = $8,500
  • Cycle 3 = $8,000

The medical fees for each cycle includes:

  • Hormonal and sonographic monitoring through blood tests and sonograms
  • Anesthesia
  • Ultrasonographic egg retrieval surgery
  • Sperm preparation
  • Intracytoplasmic Sperm Injection (ICSI)
  • Assisted Hatching (AH)
  • Embryo culture
  • Embryo transfer

Not included in the medical fee for each of the 3 cycles:

  • Fertility medications
  • Embryo cryopreservation
  • Blastocyst culture

Pioneering IVF Specialist


Increase your chances of getting pregnant from a cutting edge IVF provider. Dr. Hugh Melnick invites you to meet with him personally at Advanced Fertility Services in Manhattan or via Skype Consultation. To schedule a consultation, please click the icon below – or, call 212.369.8700.